Cortical plasticity induced by inhibitory neuron transplantation.

Supporting Online Material for Cortical Plasticity Induced by Inhibitory Neuron Transplantation

Inhibitory Neuron Transplantation into Adult Visual Cortex Creates a New Critical Period that Rescues Impaired Vision

The maturation of inhibitory circuits in juvenile visual cortex triggers a critical period in the development of the visual system. Although several manipulations of inhibition can alter the timing of the critical period, none have demonstrated the creation of a new critical period in adulthood. We developed a transplantation method to reactivate critical period plasticity in the adult visual c...

Healing Pains of the Past Using Neuronal Transplantation

Yang et al. (2016) show that transplantation of GABAergic inhibitory neurons into the amygdala boosts the persistence of fear extinction in mice. Transplantation was found to degrade perineuronal nets on endogenous inhibitory neurons and enhance synaptic plasticity in host amygdala.

Elimination of Inhibitory Synapses Is a Major Component of Adult Ocular Dominance Plasticity

During development, cortical plasticity is associated with the rearrangement of excitatory connections. While these connections become more stable with age, plasticity can still be induced in the adult cortex. Here we provide evidence that structural plasticity of inhibitory synapses onto pyramidal neurons is a major component of plasticity in the adult neocortex. In vivo two-photon imaging was...

Inhibitory Plasticity in Auditory Cortex

Arguably the most important property of neuronal circuits in general, and of cortical circuits in particular, is plasticity--the ability to change in response to past experience. While many studies of plasticity emphasize changes in excitatory transmission, in this issue of Neuron, Galindo-Leon et al. demonstrate the important role that increased inhibition may play in shaping cortical response...